Natural Products for Drug and Supplement Development
The fields of medicinal chemistry, synthetic organic chemistry, molecular modeling, natural product chemistry, and fluorine chemistry are combined in our laboratory for creating innovative approaches for drug discovery and dietary supplement development. Our group develops novel therapeutics for diseases that have no or few existing treatment options, including neurodegenerative disorders, drug addiction, and cancer. Each research project starts with natural products as the initial inspiration for drug discovery.
Currently, our research is focused on flavonoids, in which we directly modify their structures, develop strategies for the total synthesis of these novel targets, and explore their biological activities. We have designed and synthesized fluorinated derivatives of flavones, which show enhanced antioxidant activity. Additionally, quantitative 19F NMR is a method that is frequently utilized in our projects for monitoring antioxidant activities, prodrug conversion, and reaction progression.